The emergence of rapid diagnostic techniques in clinical microbiology have the potential to profoundly impact the care of patients with infectious diseases. Paramount to the successful implementation of such methods is careful coordination and communication with antimicrobial stewardship programs and the clinicians that will act on the results.
The most challenging rapid diagnostic assays to successfully implement are those that predict antimicrobial susceptibility based on the detection of molecular markers of resistance. Contributing to this challenge, current methods used in clinical microbiology laboratories to predict antimicrobial resistance in bacteria occasionally yield results that are inconsistent with observed antimicrobial susceptibility phenotypes. Such discrepancies are sometimes method specific and may arise as a consequence of a variety of factors. When these discrepancies occur, they often present a dilemma for clinical laboratory scientists and clinical microbiologists charged with interpreting and reporting results in a way that is clinically useful.
In a webinar on September 7, Thomas Kirn, MD, PhD will briefly review current methods used in clinical microbiology laboratories to identify molecular markers of resistance in bacteria with a special emphasis on method dependent limitations of such assays. Dr. Kirn will then discuss possible approaches to resolving genotype/phenotype discrepancies when they arise, result reporting options, and provide examples of possible approaches to communicating results in an effective way.